Your Location：Home >Products >Intermediates >138229-59-1
Purity:99%
Poly (ADP-ribose) polymerase-1 (PARP1) i...
The invention belongs to the field of ch...
The invention discloses a derivative bas...
The present invention relates to novel p...
methyl 3-(bromomethyl)-2-nitrobenzoate
3-formyl-2-nitrobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 16h;
Molecular sieve;
|
85.2% |
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 2h;
Molecular sieve;
Inert atmosphere;
|
78% |
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
|
74% |
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 12h;
|
54% |
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
Molecular sieve;
|
|
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
Molecular sieve;
Inert atmosphere;
|
3.92 g |
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
Molecular sieve;
|
|
|
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
Molecular sieve;
|
methyl 3-methyl-2-nitrobenzoate
3-formyl-2-nitrobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
With
manganese(IV) oxide; nitric acid;
at 40 ℃;
|
66.4% |
|
methyl 3-methyl-2-nitrobenzoate;
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
acetonitrile;
for 12h;
Reflux;
With
4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 3h;
|
40% |
|
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / tetrachloromethane
2: 4-methylmorpholine N-oxide / acetonitrile / Molecular sieve
With
N-Bromosuccinimide; 4-methylmorpholine N-oxide;
In
tetrachloromethane; acetonitrile;
|
|
|
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 30 h / 130 °C / Large scale reaction
2: sodium periodate / water; N,N-dimethyl-formamide / 3 h / 45 °C / Large scale reaction
With
sodium periodate;
In
water; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 18 h / 130 °C
2: sodium periodate / N,N-dimethyl-formamide / 3.5 h / 20 °C
With
sodium periodate;
In
N,N-dimethyl-formamide;
|
|
|
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 12 h / Heating / reflux
2: 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve
With
N-Bromosuccinimide; 4-methylmorpholine N-oxide; dibenzoyl peroxide;
In
tetrachloromethane; acetonitrile;
|
|
|
methyl 3-methyl-2-nitrobenzoate;
With
N,N-dimethyl-formamide dimethyl acetal;
In
N,N-dimethyl-formamide;
at 130 ℃;
With
sodium periodate;
In
water;
at 20 - 45 ℃;
Reagent/catalyst;
Temperature;
|
155 g |
|
Multi-step reaction with 2 steps
1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 12 h / Reflux; Inert atmosphere
2: 4-methylmorpholine N-oxide / acetonitrile / 2 h / 20 °C / Molecular sieve; Inert atmosphere
With
N-Bromosuccinimide; 4-methylmorpholine N-oxide; dibenzoyl peroxide;
In
tetrachloromethane; acetonitrile;
|
|
|
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 48 h / 15 - 80 °C
2: 4-methylmorpholine N-oxide / acetonitrile / 16 h / 20 °C / Molecular sieve
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 4-methylmorpholine N-oxide;
In
tetrachloromethane; acetonitrile;
|
methyl 3-(bromomethyl)-2-nitrobenzoate
methyl 3-[2-(E)-(dimethylamino)ethenyl]-2-nitro-benzoate
methyl 3-methyl-2-nitrobenzoate
β-(dimethylamino)-3-carbomethoxy-2-nitrostyrene
tert-butyl 6-({(1E)-[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)-3,4-dihydro-(1H)-isoquinoline-2-carboxylate
C25H29N3O6
methyl 3-(morpholin-4-ylmethyl)-2-nitrobenzoate
18-(nitrobenzylideneamino)phenylpiperidine-1-carboxylate
CAS：195875-84-4
CAS：2023788-19-2
CAS：1171197-20-8
