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880468-89-3

  • Product Name:(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate
  • Molecular Formula:C16H24 N2 O4
  • Molecular Weight:308.378
Inquiry

Product Details

pd_meltingpoint:63-64 °C

Purity:99%

Manufacturer supply high quality (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate 880468-89-3 with GMP standards

  • Molecular Formula:C16H24 N2 O4
  • Molecular Weight:308.378
  • Melting Point:63-64 °C 
  • Boiling Point:507.6±50.0 °C(Predicted) 
  • PKA:10.62±0.46(Predicted) 
  • PSA：76.66000 
  • Density:1.103±0.06 g/cm3(Predicted) 
  • LogP:2.62430 

880468-89-3 Relevant articles

Preparation method of lacosamide

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Paragraph 0033-0034, (2020/07/02)

The invention provides a novel methylati...

Improved Synthesis and Impurity Identification of (R)-Lacosamide

Yang, Anjiang,Hu, Feifei,Li, Zhong,Chen, Mengdi,Cai, Jianguang,Wang, Linghui,Zhang, Tao,Zhao, Chuanmeng,Zhang, Fuli

, p. 818 - 824 (2019/04/01)

An improved synthesis of Lacosamide 1 wi...

AN IMPROVED PROCESS FOR THE PREPARATION OF LACOSAMIDE

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, (2018/04/17)

The present invention relates to an impr...

A raco amide intermediate of methylation method (by machine translation)

-

Paragraph 0043; 0044; 0046; 0048; 0049, (2017/07/21)

The invention is mainly discloses a synt...

880468-89-3 Process route

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
Conditions Yield
With tetrabutylammomium bromide; potassium hydroxide; In toluene; at -1 - 2 ℃; Solvent; Reagent/catalyst; Temperature;
80%
With tetrabutylammomium bromide; potassium hydroxide; In water; toluene; at 20 ℃; for 3h; Reagent/catalyst;
60.97g
With tetrabutylammomium bromide; sodium hydroxide; In water; at 20 ℃; for 3h;
38.5 g
With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 20 ℃; for 3h;
38.5 g
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
Conditions Yield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Green chemistry;
81%

880468-89-3 Upstream products

  • 100-46-9
    100-46-9

    benzylamine

  • 86123-95-7
    86123-95-7

    (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid

  • 1253790-58-7
    1253790-58-7

    tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

  • 77-78-1
    77-78-1

    dimethyl sulfate

880468-89-3 Downstream products

  • 175481-36-4
    175481-36-4

    lacosamide

  • 1322062-76-9
    1322062-76-9

    (R)-2-amino-N-benzyl-3-methoxypropionamide hydrochloride

  • 196601-69-1
    196601-69-1

    (R)-2-amino-N-benzyl-3-methoxypropanamide

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