What is the GDC-0077?

GDC-0077 is , while it's Molecular Formula is C 18 H 19 F 2 N 5 O 4 . Used in Oncology: GDC-0077 is used as a targeted therapy for various cancer types, including breast cancer and other solid tumors with PIK3CA mutations. It works by inhibiting the PI3K pathway, which is crucial for cancer cell growth and survival, leading to the suppression of tumor progression. Used in Clinical Trials: GDC-0077 is currently being evaluated in clinical trials to assess its potential as a targeted therapy for various cancer types. Early results have shown encouraging efficacy and a favorable safety profile, indicating its potential as a valuable treatment option for cancer patients. Used in Drug Development: As a potent and selective PI3K inhibitor, GDC-0077 serves as a valuable compound in the development of new cancer therapies. Its ability to target a specific signaling pathway involved in cancer cell growth and survival makes it a promising candidate for further research and development in the field of oncology.

What is the CAS number for GDC-0077?

The CAS number of GDC-0077 is 2060571-02-8.

What is GDC-0077 (2060571-02-8) used for?

GDC-0077 is a potent and selective inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, a key signaling pathway involved in cell growth, survival, and metabolism. It specifically inhibits the alpha isoform of the PI3K protein, thereby suppressing downstream signaling events that promote cancer cell proliferation and survival. GDC-0077 has demonstrated promising anti-tumor activity in preclinical studies, particularly in breast cancer and other solid tumors with PIK3CA mutations.

What is the GDC-0077?

GDC-0077 is , while it's Molecular Formula is C 18 H 19 F 2 N 5 O 4 . Used in Oncology: GDC-0077 is used as a targeted therapy for various cancer types, including breast cancer and other solid tumors with PIK3CA mutations. It works by inhibiting the PI3K pathway, which is crucial for cancer cell growth and survival, leading to the suppression of tumor progression. Used in Clinical Trials: GDC-0077 is currently being evaluated in clinical trials to assess its potential as a targeted therapy for various cancer types. Early results have shown encouraging efficacy and a favorable safety profile, indicating its potential as a valuable treatment option for cancer patients. Used in Drug Development: As a potent and selective PI3K inhibitor, GDC-0077 serves as a valuable compound in the development of new cancer therapies. Its ability to target a specific signaling pathway involved in cancer cell growth and survival makes it a promising candidate for further research and development in the field of oncology.

What is the CAS number for GDC-0077?

The CAS number of GDC-0077 is 2060571-02-8.

What is GDC-0077 (2060571-02-8) used for?

GDC-0077 is a potent and selective inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, a key signaling pathway involved in cell growth, survival, and metabolism. It specifically inhibits the alpha isoform of the PI3K protein, thereby suppressing downstream signaling events that promote cancer cell proliferation and survival. GDC-0077 has demonstrated promising anti-tumor activity in preclinical studies, particularly in breast cancer and other solid tumors with PIK3CA mutations.

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2060571-02-8

Product Name:CPD1573
Molecular Weight:407.377

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Product Details

Purity:99%

Quality Factory Supply 99% Pure CPD1573 2060571-02-8 with Efficient Delivery

Molecular Formula:C₁₈H₁₉F₂N₅O₄
Molecular Weight:407.377

2060571-02-8 Relevant articles

Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids

Han,Kelly, Sean M.,Cravillion, Theresa,Savage, Scott J.,Nguyen, Tina,Gosselin, Francis

, p. 4351 - 4357 (2019/05/10)

An efficient synthesis of PI3K inhibitor...

POLYMORPHS AND SOLID FORMS OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE, AND METHODS OF PRODUCTION

-

Page/Page column 32, (2018/11/22)

The present invention relates to crystal...

PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE

-

Page/Page column 17; 22; 23, (2018/07/05)

Methods of making benzoxazepin oxazolidi...

BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE

-

Paragraph 78, (2017/01/26)

Described herein are benzoxazepin oxazol...

2060571-02-8 Process route

: ammonium (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propionate

: 2060571-02-8
(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; at 10 ℃; for 20h; Large scale;	83%
With 1-hydroxy-pyrrolidine-2,5-dione; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; at 10 ℃; for 20h; Inert atmosphere; Large scale;	83%

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one

: 2060571-02-8
(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide

Conditions

Conditions	Yield
L-alanin; (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one; With potassium phosphate; In dimethyl sulfoxide; at 100 ℃; for 2h; With ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 1.08333h;	46%
L-alanin; (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one; With potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 100 ℃; for 2h; With ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 1h;	46%

Yield

L-alanin; (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one; With potassium phosphate; In dimethyl sulfoxide; at 100 ℃; for 2h;

With ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 1.08333h;

46%

L-alanin; (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one; With potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 100 ℃; for 2h;

46%

2060571-02-8 Upstream products

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9-bromo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine
1282516-68-0
9-bromo-2,3-diiodo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine
1282516-69-1
9-bromo-2-iodo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine
591-20-8
3-Bromophenol

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