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1029716-44-6

  • Product Name:1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • Molecular Formula:C13H23BN2O3
  • Molecular Weight:266.148
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Product Details

Purity:99%

Factory Export Top Purity 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1029716-44-6 In Stock

  • Molecular Formula:C13H23BN2O3
  • Molecular Weight:266.148
  • Boiling Point:353.3±22.0 °C(Predicted) 
  • PKA:1.55±0.10(Predicted) 
  • PSA：45.51000 
  • Density:1.06 
  • LogP:1.73730 

1029716-44-6 Relevant articles

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Yao, Lianbin,Mustafa, Nurulhuda,Tan, Eng Chong,Poulsen, Anders,Singh, Prachi,Duong-Thi, Minh-Dao,Lee, Jeannie X. T.,Ramanujulu, Pondy Murugappan,Chng, Wee Joo,Yen, Jeffrey J. Y.,Ohlson, Sten,Dymock, Brian W.

, p. 8336 - 8357 (2017)

Concomitant inhibition of multiple oncog...

PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR

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Paragraph 0120; 0123, (2019/08/22)

This invention relates to processes and ...

Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90)

Yao, Lianbin,Ohlson, Sten,Dymock, Brian W.

, p. 1357 - 1362 (2018/03/21)

Inhibition of multiple signaling pathway...

ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES

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Page/Page column 82, (2017/09/02)

Compounds having the following formula I...

1029716-44-6 Process route

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole
1024120-52-2

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1195-66-0

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
1029716-44-6

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions
Conditions Yield
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With isopropyl magnesium chloride - lithium chloride complex; In tetrahydrofuran; at 20 - 25 ℃; for 16h;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 25 ℃; for 2h;
99%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; In tetrahydrofuran; at 20 ℃;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 20 ℃; for 2h;
99%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; In tetrahydrofuran; at 20 ℃;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 20 ℃; for 2h;
99%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 10 ℃; Inert atmosphere;
56.4%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; at 20 ℃; for 12h;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; at -20 - 10 ℃;
56.4%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; In tetrahydrofuran; at 20 ℃; for 12h;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 10 ℃; for 1h;
With water; ammonium chloride; In tetrahydrofuran;
56.4%
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With TurboGrignard; In tetrahydrofuran; at 20 ℃; for 12h;
2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 10 ℃; for 1h;
4.2 g
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole
1024120-52-2

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
1029716-44-6

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Conditions
Conditions Yield
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 50 ℃; for 16h; Inert atmosphere;
68.5%
With potassium acetate; In 1,4-dioxane;
68.5%

1029716-44-6 Upstream products

  • 1024120-52-2
    1024120-52-2

    4-bromo-1-(1-ethoxyethyl)-1H-pyrazole

  • 1195-66-0
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    2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • 61676-62-8
    61676-62-8

    2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • 575452-22-1
    575452-22-1

    1-(1-ethoxyethyl)-4-iodo-1H-pyrazole

1029716-44-6 Downstream products

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    2-(1-(ethanesulfonyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-3-yl)acetonitrile

  • 1269822-91-4
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    4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-c]pyridazine

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    1269823-73-5

    7-benzyl-4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d][1,2,3]triazine-5-carbonitrile

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