pd_meltingpoint:159-161 °C
Appearance:white crystalline powder
Purity:99%
|
Air & Water Reactions |
Water soluble. |
|
Health Hazard |
SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma. |
|
Fire Hazard |
Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible. |
|
Biochem/physiol Actions |
Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion. |
|
Veterinary Drugs and Treatments |
In small animal medicine propantheline bromide has been used for its antispasmodic/antisecretory effects in the treatment of diarrhea. It is also employed in the treatment of hyperreflexic detrusor or urge incontinence and as oral treatment in anticholinergic responsive bradycardias. In horses, propantheline has been used intravenously to reduce colonic peristalsis and for relaxing the rectum to allow easier rectal examination and surgery. |
|
General Description |
Propantheline bromide,2-hydroxy-ethyl)diisopropylmethylammonium bromidexanthene-9-carboxylate (Pro-Banthine), is prepared in amanner exactly analogous to that used for methanthelinebromide. It is a white, water-soluble, crystalline substance,with properties quite similar to those of methantheline bromide.Its chief difference from methantheline bromide is inits potency, which has been estimated variously to be 2 to5 times as great. |
InChI:InChI=1/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H
methyl bromide
propantheline bromide
| Conditions | Yield |
|---|---|
|
With
chloroform;
|
propantheline bromide
xanthene-9-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
water;
at 100 ℃;
for 1.16667h;
pH=7.0;
Further Variations:;
pH-values;
Kinetics;
|
methyl bromide
xanthene-9-carboxylic acid
propantheline p-toluenesulfonate
CAS：329-63-5
CAS：4264-93-1
