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Purity:99%
This invention provides compounds, compo...
This invention provides compounds, compo...
The synthesis of ten proline-modified an...
A series of GPE analogues, including mod...
N-benzyloxycarbonyl-glycyl-L-2-methylproline
L-glutamic acid dibenzyl ester 4-toluenesulfonate
dibenzyl N-benzyloxycarbonyl-glycyl-L-2-methylprolyl-L-glutamate
| Conditions | Yield |
|---|---|
|
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 17h;
|
89% |
|
N-benzyloxycarbonyl-glycyl-L-2-methylproline; L-glutamic acid dibenzyl ester 4-toluenesulfonate;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
dichloromethane;
for 17h;
|
89% |
|
N-benzyloxycarbonyl-glycyl-L-2-methylproline; L-glutamic acid dibenzyl ester 4-toluenesulfonate;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
dichloromethane;
at 20 ℃;
for 17h;
Inert atmosphere;
|
89% |
methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride
dibenzyl N-benzyloxycarbonyl-glycyl-L-2-methylprolyl-L-glutamate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
2: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
3: 89 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 17 h / 20 °C
With
sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
1,4-dioxane; dichloromethane;
|
|
|
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: sodium hydroxide; water / 1,4-dioxane / 19 h / 20 °C
3.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
3.2: 17 h
With
water; triethylamine; sodium hydroxide;
In
1,4-dioxane; dichloromethane;
|
|
|
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
1.2: 20 h / 0 - 20 °C
2.1: sodium hydroxide; water / 1,4-dioxane / 19 h / 20 °C
3.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
3.2: 17 h / 20 °C / Inert atmosphere
With
water; triethylamine; sodium hydroxide;
In
1,4-dioxane; dichloromethane;
|
(S)-2-[((S)-2-Methyl-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester
N-(Benzyloxycarbonyl)glycine
N-benzyloxycarbonyl-glycyl-L-2-methylproline
L-glutamic acid dibenzyl ester 4-toluenesulfonate
glycyl-L-2-methylprolyl-L-glutamic acid
C14H23N3O6
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