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868539-96-2

  • Product Name:Boc-HPh-Leu-Phe-OMe
  • Molecular Formula:C31H43N3O6
  • Molecular Weight:553.699
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Product Details

Purity:99%

High Quality Chinese Factory supply 868539-96-2 Boc-HPh-Leu-Phe-OMe

  • Molecular Formula:C31H43N3O6
  • Molecular Weight:553.699
  • Boiling Point:753.4±60.0 °C(Predicted) 
  • PKA:11.22±0.46(Predicted) 
  • PSA:122.83000 
  • Density:1.123±0.06 g/cm3(Predicted) 
  • LogP:5.11660 

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PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE

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The present invention relates to process...

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The invention relates to crystalline pep...

868539-96-2 Process route

Boc-L-homophenylalanine
82732-07-8,108524-68-1,142926-43-0,100564-78-1

Boc-L-homophenylalanine

Leu-Phe-OMe trifluoroacetate

Leu-Phe-OMe trifluoroacetate

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
Conditions Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
15136-32-0,87976-66-7,120342-25-8,5874-73-7

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

Boc-L-homophenylalanine
82732-07-8,108524-68-1,142926-43-0,100564-78-1

Boc-L-homophenylalanine

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
Conditions Yield
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
Boc-L-homophenylalanine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
21.59 g
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester; With trifluoroacetic acid; In dichloromethane;
Boc-L-homophenylalanine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
246 mg

868539-96-2 Upstream products

  • 82732-07-8
    82732-07-8

    Boc-L-homophenylalanine

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    13734-34-4

    N-tert-butoxycarbonyl-L-phenylalanine

  • 38155-18-9
    38155-18-9

    L-leucyl-L-phenylalanine methyl ester

  • 13139-15-6
    13139-15-6

    N-tert-butoxycarbonyl-L-leucine

868539-96-2 Downstream products

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    C32H44N4O6

  • 868540-16-3
    868540-16-3

    (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

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