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Purity:99%
A series of novel tetrapeptidyl epoxyket...
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The invention relates to crystalline pep...
Boc-L-homophenylalanine
Leu-Phe-OMe trifluoroacetate
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
| Conditions | Yield |
|---|---|
|
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
|
|
|
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
|
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
Boc-L-homophenylalanine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
| Conditions | Yield |
|---|---|
|
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Boc-L-homophenylalanine;
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
|
21.59 g |
|
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
Boc-L-homophenylalanine;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
|
246 mg |
Boc-L-homophenylalanine
N-tert-butoxycarbonyl-L-phenylalanine
L-leucyl-L-phenylalanine methyl ester
N-tert-butoxycarbonyl-L-leucine
C2HF3O2*C26H35N3O4
C28H36ClN3O5
C32H44N4O6
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
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