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1187595-85-2

  • Product Name:2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
  • Molecular Formula:C7H10N2O2S
  • Molecular Weight:186.235
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Product Details

Purity:99%

Factory sells 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2 with sufficient production capacity

  • Molecular Formula:C7H10N2O2S
  • Molecular Weight:186.235
  • Boiling Point:360.8±52.0 °C(Predicted) 
  • PKA:-8.49±0.20(Predicted) 
  • PSA：69.55000 
  • Density:1.33±0.1 g/cm3(Predicted) 
  • LogP:1.12038 

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1187595-85-2 Process route

diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

1-(ethylsulfonyl)azetidin-3-one

1-(ethylsulfonyl)azetidin-3-one

2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile
1187595-85-2

2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile

Conditions
Conditions Yield
diethyl 1-cyanomethylphosphonate; With potassium tert-butylate; In tetrahydrofuran; at -10 - 0 ℃; Inert atmosphere;
1-(ethylsulfonyl)azetidin-3-one; In tetrahydrofuran; at -10 - 20 ℃; Solvent; Inert atmosphere;
68.5%
diethyl 1-cyanomethylphosphonate; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 3.5h;
1-(ethylsulfonyl)azetidin-3-one; In tetrahydrofuran; at 0 - 20 ℃; for 18h;
35%
With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 0 - 10 ℃; for 20h;
diethyl cyanomethyl phosphonate
50586-62-4

diethyl cyanomethyl phosphonate

1-(ethylsulfonyl)azetidin-3-one

1-(ethylsulfonyl)azetidin-3-one

2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile
1187595-85-2

2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile

Conditions
Conditions Yield
diethyl cyanomethyl phosphonate; With sodium methylate; In tetrahydrofuran; at 10 - 20 ℃; for 0.75h; Inert atmosphere;
1-(ethylsulfonyl)azetidin-3-one; In tetrahydrofuran; at 30 ℃; for 11h;
96.4%

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1187595-85-2 Downstream products

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    2-(1-(ethanesulfonyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-3-yl)acetonitrile

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    Baricitinib

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    (4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

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