2353-33-5

Quality Manufacturer Supply High Purity 99% 5-Aza-2'-deoxycytidine 2353-33-5 with Reasonable Price We supply high quality 5-Aza-2'-deoxycytidine (CAS 2353-33-5), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the 5-Aza-2'-deoxycytidine ?

5-Aza-2'-deoxycytidine is white crystalline powder, while it's Molecular Formula is C₈H₁₂N₄O₄. Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively

What is the CAS number for 5-Aza-2'-deoxycytidine ?

The CAS number of 5-Aza-2'-deoxycytidine is 2353-33-5.

More information of 5-Aza-2'-deoxycytidine 2353-33-5 are:

What is 5-Aza-2'-deoxycytidine (2353-33-5) used for?

Decitabine, 5-aza-2’-deoxycytidine, has been launched for the treatment of myelodysplastic syndromes (MDS). MDS are a set of hematologic disorders affecting the bone marrow that result in ineffective formation and development of blood cells. Furthermore, patients with MDS have a high risk of progressing to acute myeloid leukemia (AML). Traditional treatments include blood transfusions, hematopoietic growth factors, and prophylactic antibiotics, but these measures merely improve the quality of life with questionable effects on disease modification. While stem-cell transplantation is an aggressive, potentially curative approach, the advanced age or the other complicating health issues of most patients preclude them from considering this option. Recent advances in the underlying etiology of MDS, however, have led to the development of a new class of compounds known as ‘‘demethylating agents’’. Decitabine follows the successful introduction of the first DNA methyltransferase inhibitor azacitidine.

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How to get the best price on 5-Aza-2'-deoxycytidine?

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