pd_meltingpoint:214 °C
Appearance:white or off-white crystalline powder
Purity:99%
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Cytarabine (cytosine arabinoside, ara-C, Cytosar-U) is an analogue of the pyrimidine nucleosides cytidine and deoxycytidine. It is one of the most active agents available for the treatment of acute myelogenous leukemia. Cytarabine kills cells in the S-phase of the cycle by competitively inhibiting DNA polymerase. The drug must first be activated by pyrimidine nucleoside kinases to the triphosphate nucleotide ara-cytosine triphosphate (ara-CTP). The susceptibility of tumor cells to cytarabine is thought to be a reflection of their ability to activate the drug more rapidly (by kinases) than to inactivate it (by deaminases).
Cytarabine USP (Cytosar)is used to treat Acute granulocytic leukemia (adults); acute lymphocytic leukemia (children); Hodgkin’s disease
4-Amino-1-((2R,3S,4R,5R)-4-bromo-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one; hydrochloride
cyclocitidine
arabinosyl cytosine
| Conditions | Yield |
|---|---|
|
With
sodium hydrogencarbonate;
In
water-d2;
for 168h;
or 1-(3-iodo-3-deoxy-β-D-xylofuranosyl)cytosine hydrochloride (2c);
|
![N-[1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-succinamic acid benzyl ester](/upload/2026/7/d1501018-2e88-4768-b48a-27d61e26d9be.png)
N-[1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-succinamic acid benzyl ester
succinic acid monobenzyl ester
arabinosyl cytosine
| Conditions | Yield |
|---|---|
|
With
sodium hydrogencarbonate; sodium carbonate;
at 25 ℃;
Rate constant;
various pH;
|
The CAS number of Cytarabine is 147-94-4.
More information of Cytarabine 147-94-4 are:
|
CAS Number |
147-94-4 |
|
Density |
1.89 g/cm3 |
|
Melting Point |
214 °C |
|
Boiling Point |
545.7 °C at 760 mmHg |
|
Flash Point |
283.8 °C |
|
Vapor Pressure |
3.5E-14mmHg at 25°C |
|
Refractive Index |
1.5100 (estimate) |
|
HS CODE |
PRICE |
|
PSA |
130.83000 |
|
LogP |
-1.98180 |
|
Pka |
pKa 4.3 (Uncertain) |
Synonyms for Cytarabine 147-94-4:2(1H)-Pyrimidinone,4-amino-1-a-Darabinofuranosyl-;U-19,920;Cytosine Arabinoside;cytarbine;Depocyt (liposomal);Arafcyt;Cytosine, 1-beta-D-arabinofuranosyl-;Cytosine-1-beta-arabinofuranoside;Depocyt (TN);Cytosine beta-D-arabinofuranoside;Erpalfa;Arabitin;Tarabine PFS;ara-Cytosine;Cytarabin;1.beta.-D-Arabinofuranosylcytosine;Udicil;NCI-C04728;.beta.-Cytosine arabinoside;Cytosar U;Aracytin;1-(beta,D-Arabinofuranosyl)cytosine;Cyclocide;2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-;1beta-D-Arabinosylcytosine;Arabinofuranosylcytosine;
The chemical formula of Cytarabine is C9H13N3O5 which containing 9 Carbon atoms,13 Hydrogen atoms,3 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of Cytarabine is 243.219.
Cytarabine (147-94-4) is a nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6
InChI:InChI=1/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6+,7?,8-/m1/s1
Relevant articles related to Cytarabine:
|
Article |
Source |
|
- |
Fromageot,Reese , p. 3499,3500 (1966) |
|
- |
Ogilvie , p. 210 (1972) |
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