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850140-73-7

  • Product Name:BIBW2992 DiMaleate
  • Molecular Formula:C24H25ClFN5O3·2C4H4O4
  • Molecular Weight:718.092
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Product Details

Purity:99%

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What is the BIBW2992 DiMaleate ?

BIBW2992 DiMaleate is , while it's Molecular Formula is 2C4H4O4*C24H25ClFN5O3. Afatinib Dimaleate is a salt of Afatinib {BIBW 2992), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.

What is the CAS number for BIBW2992 DiMaleate ?

The CAS number of BIBW2992 DiMaleate is 850140-73-7.

More information of BIBW2992 DiMaleate 850140-73-7 are:

Synonyms

 BIBW 2992MA2;

CAS Number

 850140-73-7

Molecular Formula

 2C4H4O4*C24H25ClFN5O3

Molecular Weight

 718.092

Boiling Point

 983.1 °C at 760 mmHg

Flash Point

 548.3 °C

HS CODE

 29339900

PSA

 241.30000

LogP

 4.53600

What is BIBW2992 DiMaleate (850140-73-7) used for?

Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.

Articles related to BIBW2992 DiMaleate:

Article

Source

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Paragraph 0045; 0050; 0053; 0058; 0060; 0065; 0067; 0072, (2021/07/17)

Preparation method of afatinib maleate

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, (2019/12/25)

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