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112887-68-0

  • Product Name:Raltitrexed
  • Molecular Formula:C21H22N4O6S
  • Molecular Weight:458.495
  • Appearance:yellow crystalline powder
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Product Details

pd_meltingpoint:176-180 °C

Appearance:yellow crystalline powder

Purity:99%

Purity 99% Min Raltitrexed 112887-68-0 Spot Supply with Safe Transportation We supply high quality Raltitrexed (CAS 112887-68-0), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Raltitrexed ?

Raltitrexed is yellow crystalline powder, while it's Molecular Formula is C21H22N4O6S. Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic

What is the CAS number for Raltitrexed ?

The CAS number of Raltitrexed is 112887-68-0.

More information of Raltitrexed 112887-68-0 are:

Synonyms

 D1694;Tomudex (TN);L-Glutamic acid,N-[[5-[[(1,4-dihydro-2- methyl-4-oxo-6-quinazolinyl)methyl]methylamino]- 2-thienyl]carbonyl]-;ZD1694;Raltitrexed (JAN/USAN);D 1694;(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid;L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)-;Tomudex;ICI-D1694;ICI D1694;N-(5-(N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid;(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid;ZD 1694;D-1694;

CAS Number

 112887-68-0

Molecular Formula

 C21H22N4O6S

Molecular Weight

 458.495

Density

 1.49 g/cm3

Melting Point

 176-180 °C

PSA

 180.93000

LogP

 2.36810

Pka

 3.50±0.10(Predicted)

What is Raltitrexed (112887-68-0) used for?

Tomudex was launched in Ireland, France, Luxembourg and the UK for advanced colorectal cancer and it was prepared in a convergent manner (6 steps) from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one. Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Clinically, it had a 29% response rate in patients with advanced colorectal cancer. It is water soluble, can be administered as a single dose every three weeks and had no hepto- or nephrotoxicity.

InChI:InChI=1/C20H24N4O2S/c1-12-21-15-7-6-13(10-14(15)18(25)22-12)11-24(5)17-9-8-16(27-17)19(26)23-20(2,3)4/h6-10H,11H2,1-5H3,(H,23,26)(H,21,22,25)

Articles related to Raltitrexed:

Article

Source

New synthesis of thymidylate synthase inhibitor raltitrexed

Cao, Sheng-Li,Wan, Rong,Feng, Yu-Ping

, p. 3519 - 3526 (2003)

Raltitrexed pharmaceutical composition and preparation method thereof

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Paragraph 0090; 0091, (2018/04/02)

How to get the best price on Raltitrexed?

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